| 1 |  Jim Simons (Estate) Renaissance Technologies LLC | | 421,688 | $188.30M | HOLD |
| 2 |  JPMorgan Chase JPMorgan Asset Management | | 7,033,156 | $3.12B | HOLD |
| 3 |  | | 23,969,517 | $10.70B | HOLD |
| 4 |  State Street State Street Global Advisors | | 11,730,139 | $5.24B | HOLD |
| 5 |  National Pension Service National Pension Service | | 532,069 | $237.59M | HOLD |
| 6 |  Two Sigma Two Sigma Investments LP | | 378,146 | $168.86M | HOLD |
| 7 |  Goldman Sachs Goldman Sachs Asset Management | | 2,417,875 | $1.08B | HOLD |
| 8 |  T. Rowe Price T. Rowe Price Associates | | 1,760,122 | $785.97M | HOLD |
| 9 |  David E. Shaw D.E. Shaw & Co LP | | 248,960 | $111.17M | HOLD |
| 10 |  Fidelity (FMR) Fidelity Management & Research | | 2,020,265 | $902.13M | HOLD |
| 11 |  Cliff Asness AQR Capital Management LLC | | 171,031 | $76.03M | HOLD |
| 12 |  Joel Greenblatt Gotham Asset Management LLC | | 20,887 | $9.33M | HOLD |
| 13 |  Ray Dalio Bridgewater Associates LP | | 13,357 | $5.96M | HOLD |
| 14 |  Ken Griffin Citadel Advisors LLC | | 339,298 | $151.51M | HOLD |
| 15 |  Dmitry Balyasny Balyasny Asset Management LP | | 40,137 | $17.92M | HOLD |
| 16 |  Israel Englander Millennium Management LLC | | 96,900 | $43.27M | HOLD |
| 17 |  Ron Baron Baron Capital Group Inc | | 7,500 | $3.35M | HOLD |
| 18 |  Steve Cohen Point72 Asset Management LP | | 16,600 | $7.41M | HOLD |
| 19 |  Ken Fisher Fisher Asset Management LLC | | 31,158 | $13.91M | HOLD |
| 20 |  Paul Tudor Jones Tudor Investment Corp | | 2,300 | $1.03M | HOLD |
VRTX