| 1 |  Joseph Edelman Perceptive Advisors LLC | | 1,995,986 | $588.30M | HOLD |
| 2 |  Julian Baker Baker Brothers Advisors LP | | 1,126,488 | $332.02M | HOLD |
| 3 |  Steve Cohen Point72 Asset Management LP | | 500,000 | $147.37M | HOLD |
| 4 |  Jim Simons (Estate) Renaissance Technologies LLC | | 66,230 | $19.52M | HOLD |
| 5 |  Goldman Sachs Goldman Sachs Asset Management LP | | 716,184 | $211.09M | HOLD |
| 6 |  T. Rowe Price T. Rowe Price Associates Inc | | 785,987 | $231.66M | HOLD |
| 7 |  | | 1,358,675 | $400.46M | HOLD |
| 8 |  | | 2,078,500 | $612.62M | HOLD |
| 9 |  Two Sigma Two Sigma Investments LP | | 23,098 | $6.81M | HOLD |
| 10 |  Paul Tudor Jones Tudor Investment Corp | | 16,009 | $4.72M | HOLD |
| 11 |  State Street State Street Global Advisors | | 882,215 | $260.02M | HOLD |
| 12 |  David E. Shaw D.E. Shaw & Co LP | | 37,481 | $11.05M | HOLD |
| 13 |  Vanguard Vanguard Group Inc | | 1,460,933 | $430.60M | HOLD |
| 14 |  Cliff Asness AQR Capital Management LLC | | 28,828 | $8.50M | HOLD |
| 15 |  Ken Griffin Citadel Advisors LLC | | 54,200 | $15.97M | HOLD |
| 16 |  Israel Englander Millennium Management LLC | | 9,300 | $2.74M | HOLD |
| 17 |  JPMorgan Chase JPMorgan Chase & Co | | 55,300 | $16.30M | HOLD |
| 18 |  Norges Bank Norges Bank Investment Management | | 4,354 | $1.28M | HOLD |
PRAX