| 1 |  Ron Baron Baron Capital Group Inc | | 153,719 | $129.27M | HOLD |
| 2 |  Two Sigma Two Sigma Investments LP | | 258,556 | $217.43M | HOLD |
| 3 |  Louis Bacon Moore Capital Management LP | | 25,000 | $21.02M | HOLD |
| 4 |  T. Rowe Price T. Rowe Price Associates Inc | | 3,362,324 | $2.83B | HOLD |
| 5 |  | | 5,592,319 | $4.70B | HOLD |
| 6 |  Julian Baker Baker Brothers Advisors LP | | 25,174 | $21.17M | HOLD |
| 7 |  Dmitry Balyasny Balyasny Asset Management LP | | 41,923 | $35.26M | HOLD |
| 8 |  Ken Griffin Citadel Advisors LLC | | 350,851 | $295.05M | HOLD |
| 9 |  David E. Shaw D.E. Shaw & Co LP | | 75,500 | $63.49M | HOLD |
| 10 |  Israel Englander Millennium Management LLC | | 60,458 | $50.84M | HOLD |
| 11 |  Goldman Sachs Goldman Sachs Asset Management LP | | 167,206 | $140.61M | HOLD |
| 12 |  | | 735,598 | $618.60M | HOLD |
| 13 |  Steve Cohen Point72 Asset Management LP | | 5,000 | $4.20M | HOLD |
| 14 |  Paul Tudor Jones Tudor Investment Corp | | 2,148 | $1.81M | HOLD |
| 15 |  Cliff Asness AQR Capital Management LLC | | 2,401 | $2.02M | HOLD |
| 16 |  Joel Greenblatt Gotham Asset Management LLC | | 272 | $228,738 | HOLD |
| 17 |  JPMorgan Chase JPMorgan Chase & Co | | 13,999 | $11.77M | HOLD |
| 18 |  State Street State Street Global Advisors | | 4,734 | $3.98M | HOLD |
ARGX