| 1 |  Cathie Wood ARK Investment Management LLC | | 14,207,324 | $127.72M | HOLD |
| 2 |  Two Sigma Two Sigma Investments LP | | 2,698,738 | $24.26M | HOLD |
| 3 |  David E. Shaw D.E. Shaw & Co LP | | 5,331,064 | $47.93M | HOLD |
| 4 |  Jim Simons (Estate) Renaissance Technologies LLC | | 1,672,700 | $15.04M | HOLD |
| 5 |  Ray Dalio Bridgewater Associates LP | | 223,166 | $2.01M | HOLD |
| 6 |  Paul Tudor Jones Tudor Investment Corp | | 189,076 | $1.70M | HOLD |
| 7 |  State Street State Street Global Advisors | | 6,418,836 | $57.71M | HOLD |
| 8 |  Vanguard Vanguard Group Inc | | 13,010,001 | $116.96M | HOLD |
| 9 |  Goldman Sachs Goldman Sachs Asset Management LP | | 1,455,619 | $13.09M | HOLD |
| 10 |  | | 10,276,849 | $92.39M | HOLD |
| 11 |  Cliff Asness AQR Capital Management LLC | | 313,695 | $2.82M | HOLD |
| 12 |  Ken Griffin Citadel Advisors LLC | | 950,250 | $8.54M | HOLD |
| 13 |  | | 1,759,898 | $15.82M | HOLD |
| 14 |  Israel Englander Millennium Management LLC | | 126,426 | $1.14M | HOLD |
| 15 |  JPMorgan Chase JPMorgan Chase & Co | | 743,698 | $6.69M | HOLD |
| 16 |  Steve Cohen Point72 Asset Management LP | | 24,100 | $216,659 | HOLD |
| 17 |  T. Rowe Price T. Rowe Price Associates Inc | | 121,988 | $1.10M | HOLD |
NTLA