| 1 |  Julian Baker Baker Brothers Advisors LP | | 30,744,412 | $2.89B | HOLD |
| 2 |  Jim Simons (Estate) Renaissance Technologies LLC | | 3,651,532 | $343.68M | HOLD |
| 3 |  Cliff Asness AQR Capital Management LLC | | 5,807,930 | $536.13M | HOLD |
| 4 |  Joel Greenblatt Gotham Asset Management LLC | | 676,670 | $63.69M | HOLD |
| 5 |  | | 364,657 | $34.32M | HOLD |
| 6 |  Ray Dalio Bridgewater Associates LP | | 130,296 | $12.26M | HOLD |
| 7 |  Two Sigma Two Sigma Investments LP | | 415,914 | $39.15M | HOLD |
| 8 |  State Street State Street Global Advisors | | 9,641,384 | $907.45M | HOLD |
| 9 |  | | 18,978,198 | $1.79B | HOLD |
| 10 |  Goldman Sachs Goldman Sachs Asset Management | | 2,351,221 | $221.30M | HOLD |
| 11 |  Steve Cohen Point72 Asset Management LP | | 168,763 | $15.88M | HOLD |
| 12 |  T. Rowe Price T. Rowe Price Associates | | 751,856 | $70.77M | HOLD |
| 13 |  Israel Englander Millennium Management LLC | | 172,915 | $16.27M | HOLD |
| 14 |  Fidelity (FMR) Fidelity Management & Research | | 1,172,890 | $110.39M | HOLD |
| 15 |  National Pension Service National Pension Service | | 77,489 | $7.29M | HOLD |
| 16 |  Ken Fisher Fisher Asset Management LLC | | 112,746 | $10.61M | HOLD |
| 17 |  JPMorgan Chase JPMorgan Asset Management | | 497,042 | $44.90M | HOLD |
| 18 |  Ken Griffin Citadel Advisors LLC | | 49,284 | $4.64M | HOLD |
| 19 |  Dmitry Balyasny Balyasny Asset Management LP | | 3,322 | $312,667 | HOLD |
| 20 |  Paul Tudor Jones Tudor Investment Corp | | 2,299 | $216,382 | HOLD |
| 21 |  David E. Shaw D.E. Shaw & Co LP | | 3,200 | $301,184 | HOLD |
INCY