| 1 |  Joseph Edelman Perceptive Advisors LLC | | 1,000,000 | $50.80M | HOLD |
| 2 |  Two Sigma Two Sigma Investments LP | | 9,086,404 | $461.59M | HOLD |
| 3 |  Fidelity (FMR) Fidelity Management & Research | | 45,672,024 | $2.32B | HOLD |
| 4 |  David E. Shaw D.E. Shaw & Co LP | | 2,417,000 | $122.78M | HOLD |
| 5 |  Jim Simons (Estate) Renaissance Technologies LLC | | 881,200 | $44.76M | HOLD |
| 6 |  Goldman Sachs Goldman Sachs Asset Management | | 6,603,697 | $335.47M | HOLD |
| 7 |  Steve Cohen Point72 Asset Management LP | | 446,100 | $22.66M | HOLD |
| 8 |  Ken Griffin Citadel Advisors LLC | | 3,602,000 | $182.98M | HOLD |
| 9 |  | | 29,635,876 | $1.51B | HOLD |
| 10 |  State Street State Street Global Advisors | | 14,861,409 | $754.96M | HOLD |
| 11 |  Israel Englander Millennium Management LLC | | 1,019,208 | $51.78M | HOLD |
| 12 |  Ray Dalio Bridgewater Associates LP | | 74,822 | $3.80M | HOLD |
| 13 |  Paul Tudor Jones Tudor Investment Corp | | 152,100 | $7.73M | HOLD |
| 14 |  T. Rowe Price T. Rowe Price Associates | | 738,578 | $37.52M | HOLD |
| 15 |  JPMorgan Chase JPMorgan Asset Management | | 1,317,601 | $63.55M | HOLD |
| 16 |  Cliff Asness AQR Capital Management LLC | | 38,315 | $1.91M | HOLD |
| 17 |  Dmitry Balyasny Balyasny Asset Management LP | | 5,191 | $263,703 | HOLD |
MRNA