| 1 |  Jim Simons (Estate) Renaissance Technologies LLC | | 2,418,897 | $318.67M | HOLD |
| 2 |  Two Sigma Two Sigma Investments LP | | 3,060,570 | $403.20M | HOLD |
| 3 |  Cliff Asness AQR Capital Management LLC | | 4,938,967 | $650.66M | HOLD |
| 4 |  Joseph Edelman Perceptive Advisors LLC | | 65,050 | $8.57M | HOLD |
| 5 |  Joel Greenblatt Gotham Asset Management LLC | | 360,136 | $47.44M | HOLD |
| 6 |  Ray Dalio Bridgewater Associates LP | | 148,141 | $19.52M | HOLD |
| 7 |  Israel Englander Millennium Management LLC | | 1,247,447 | $164.34M | HOLD |
| 8 |  JPMorgan Chase JPMorgan Asset Management | | 5,442,067 | $700.50M | HOLD |
| 9 |  | | 13,385,607 | $1.76B | HOLD |
| 10 |  State Street State Street Global Advisors | | 4,354,526 | $573.67M | HOLD |
| 11 |  | | 35,626 | $4.69M | HOLD |
| 12 |  David E. Shaw D.E. Shaw & Co LP | | 89,184 | $11.75M | HOLD |
| 13 |  Ken Fisher Fisher Asset Management LLC | | 122,226 | $16.10M | HOLD |
| 14 |  Goldman Sachs Goldman Sachs Asset Management | | 349,179 | $46.00M | HOLD |
| 15 |  National Pension Service National Pension Service | | 31,352 | $4.13M | HOLD |
| 16 |  T. Rowe Price T. Rowe Price Associates | | 151,256 | $19.93M | HOLD |
| 17 |  Ken Griffin Citadel Advisors LLC | | 57,968 | $7.64M | HOLD |
| 18 |  Fidelity (FMR) Fidelity Management & Research | | 154,867 | $20.40M | HOLD |
NBIX