| 1 |  T. Rowe Price T. Rowe Price Associates | | 10,037,137 | $3.30B | HOLD |
| 2 |  JPMorgan Chase JPMorgan Asset Management | | 15,596,897 | $5.09B | HOLD |
| 3 |  Jim Simons (Estate) Renaissance Technologies LLC | | 391,600 | $128.68M | HOLD |
| 4 |  National Pension Service National Pension Service | | 704,224 | $231.40M | HOLD |
| 5 |  State Street State Street Global Advisors | | 15,349,165 | $5.06B | HOLD |
| 6 |  | | 27,602,049 | $9.07B | HOLD |
| 7 |  Cliff Asness AQR Capital Management LLC | | 972,085 | $317.41M | HOLD |
| 8 |  Two Sigma Two Sigma Investments LP | | 469,215 | $154.18M | HOLD |
| 9 |  David E. Shaw D.E. Shaw & Co LP | | 600,768 | $197.41M | HOLD |
| 10 |  Joel Greenblatt Gotham Asset Management LLC | | 116,453 | $38.27M | HOLD |
| 11 |  Goldman Sachs Goldman Sachs Asset Management | | 2,669,835 | $877.28M | HOLD |
| 12 |  Mario Gabelli GAMCO Investors Inc | | 19,978 | $6.56M | HOLD |
| 13 |  Ken Fisher Fisher Asset Management LLC | | 458,475 | $150.65M | HOLD |
| 14 |  Dmitry Balyasny Balyasny Asset Management LP | | 103,993 | $34.17M | HOLD |
| 15 |  Fidelity (FMR) Fidelity Management & Research | | 2,364,394 | $776.92M | HOLD |
| 16 |  Ray Dalio Bridgewater Associates LP | | 26,410 | $8.68M | HOLD |
| 17 |  Ken Griffin Citadel Advisors LLC | | 229,100 | $75.28M | HOLD |
| 18 |  Steve Cohen Point72 Asset Management LP | | 25,240 | $8.29M | HOLD |
| 19 |  Israel Englander Millennium Management LLC | | 55,700 | $18.30M | HOLD |
| 20 |  Paul Tudor Jones Tudor Investment Corp | | 9,400 | $3.09M | HOLD |
| 21 |  Ron Baron Baron Capital Group Inc | | 5,500 | $1.81M | HOLD |
SYK