| 1 |  Two Sigma Two Sigma Investments LP | | 3,120,631 | $231.74M | HOLD |
| 2 |  David E. Shaw D.E. Shaw & Co LP | | 2,545,486 | $189.03M | HOLD |
| 3 |  Ray Dalio Bridgewater Associates LP | | 259,459 | $19.27M | HOLD |
| 4 |  Jim Simons (Estate) Renaissance Technologies LLC | | 365,772 | $27.16M | HOLD |
| 5 |  Ken Griffin Citadel Advisors LLC | | 3,173,940 | $235.70M | HOLD |
| 6 |  Dmitry Balyasny Balyasny Asset Management LP | | 350,096 | $26.00M | HOLD |
| 7 |  T. Rowe Price T. Rowe Price Associates | | 3,801,655 | $282.31M | HOLD |
| 8 |  Israel Englander Millennium Management LLC | | 633,283 | $47.03M | HOLD |
| 9 |  | | 14,207,757 | $1.06B | HOLD |
| 10 |  Goldman Sachs Goldman Sachs Asset Management | | 1,897,716 | $140.92M | HOLD |
| 11 |  State Street State Street Global Advisors | | 4,934,320 | $366.42M | HOLD |
| 12 |  Fidelity (FMR) Fidelity Management & Research | | 2,343,754 | $174.05M | HOLD |
| 13 |  Ken Fisher Fisher Asset Management LLC | | 351,628 | $26.11M | HOLD |
| 14 |  JPMorgan Chase JPMorgan Asset Management | | 1,312,259 | $91.02M | HOLD |
| 15 |  Cliff Asness AQR Capital Management LLC | | 160,112 | $11.89M | HOLD |
| 16 |  Paul Tudor Jones Tudor Investment Corp | | 28,300 | $2.10M | HOLD |
| 17 |  Steve Cohen Point72 Asset Management LP | | 23,600 | $1.75M | HOLD |
BBIO