| 1 |  Joseph Edelman Perceptive Advisors LLC | | 7,434,033 | $70.77M | HOLD |
| 2 |  Two Sigma Two Sigma Investments LP | | 6,392,628 | $60.86M | HOLD |
| 3 |  Ray Dalio Bridgewater Associates LP | | 638,054 | $6.07M | HOLD |
| 4 |  Jim Simons (Estate) Renaissance Technologies LLC | | 776,990 | $7.40M | HOLD |
| 5 |  Joel Greenblatt Gotham Asset Management LLC | | 312,961 | $2.98M | HOLD |
| 6 |  Ken Fisher Fisher Asset Management LLC | | 2,733,253 | $26.02M | HOLD |
| 7 |  State Street State Street Global Advisors | | 12,208,360 | $116.22M | HOLD |
| 8 |  | | 22,650,988 | $215.64M | HOLD |
| 9 |  Goldman Sachs Goldman Sachs Asset Management | | 2,347,443 | $22.35M | HOLD |
| 10 |  Dmitry Balyasny Balyasny Asset Management LP | | 186,125 | $1.77M | HOLD |
| 11 |  Cliff Asness AQR Capital Management LLC | | 440,141 | $4.19M | HOLD |
| 12 |  David E. Shaw D.E. Shaw & Co LP | | 302,101 | $2.88M | HOLD |
| 13 |  Paul Tudor Jones Tudor Investment Corp | | 95,700 | $911,064 | HOLD |
| 14 |  Ken Griffin Citadel Advisors LLC | | 1,018,743 | $9.70M | HOLD |
| 15 |  JPMorgan Chase JPMorgan Asset Management | | 1,541,978 | $14.57M | HOLD |
| 16 |  Israel Englander Millennium Management LLC | | 187,721 | $1.79M | HOLD |
| 17 |  Fidelity (FMR) Fidelity Management & Research | | 633,132 | $6.03M | HOLD |
| 18 |  T. Rowe Price T. Rowe Price Associates | | 230,996 | $2.20M | HOLD |
BCRX