| 1 |  Julian Baker Baker Brothers Advisors LP | | 2,047,727 | $153.76M | HOLD |
| 2 |  Joseph Edelman Perceptive Advisors LLC | | 504,000 | $37.85M | HOLD |
| 3 |  Two Sigma Two Sigma Investments LP | | 5,857,629 | $439.85M | HOLD |
| 4 |  Cathie Wood ARK Investment Management LLC | | 288,716 | $21.68M | HOLD |
| 5 |  Fidelity (FMR) Fidelity Management & Research | | 24,556,637 | $1.84B | HOLD |
| 6 |  Jim Simons (Estate) Renaissance Technologies LLC | | 305,549 | $22.94M | HOLD |
| 7 |  Israel Englander Millennium Management LLC | | 1,051,506 | $78.96M | HOLD |
| 8 |  T. Rowe Price T. Rowe Price Associates | | 3,025,251 | $227.17M | HOLD |
| 9 |  Joel Greenblatt Gotham Asset Management LLC | | 98,968 | $7.43M | HOLD |
| 10 |  David E. Shaw D.E. Shaw & Co LP | | 429,599 | $32.26M | HOLD |
| 11 |  Goldman Sachs Goldman Sachs Asset Management | | 1,699,847 | $127.64M | HOLD |
| 12 |  | | 10,442,476 | $784.13M | HOLD |
| 13 |  Ken Griffin Citadel Advisors LLC | | 942,534 | $70.77M | HOLD |
| 14 |  JPMorgan Chase JPMorgan Asset Management | | 2,363,567 | $171.41M | HOLD |
| 15 |  State Street State Street Global Advisors | | 3,995,564 | $300.03M | HOLD |
| 16 |  Ron Baron Baron Capital Group Inc | | 45,000 | $3.38M | HOLD |
| 17 |  Paul Tudor Jones Tudor Investment Corp | | 48,244 | $3.62M | HOLD |
| 18 |  Ken Fisher Fisher Asset Management LLC | | 141,544 | $10.63M | HOLD |
| 19 |  Steve Cohen Point72 Asset Management LP | | 20,000 | $1.50M | HOLD |
| 20 |  Cliff Asness AQR Capital Management LLC | | 28,783 | $2.16M | HOLD |
IONS