| 1 |  Mason Hawkins Southeastern Asset Management Inc | | 130,662 | $100.95M | HOLD |
| 2 |  Two Sigma Two Sigma Investments LP | | 812,236 | $627.57M | HOLD |
| 3 |  Cliff Asness AQR Capital Management LLC | | 1,231,008 | $946.01M | HOLD |
| 4 |  National Pension Service National Pension Service | | 371,551 | $287.08M | HOLD |
| 5 |  JPMorgan Chase JPMorgan Asset Management | | 4,311,806 | $3.23B | HOLD |
| 6 |  Joel Greenblatt Gotham Asset Management LLC | | 82,846 | $64.01M | HOLD |
| 7 |  T. Rowe Price T. Rowe Price Associates | | 2,177,527 | $1.68B | HOLD |
| 8 |  Steve Cohen Point72 Asset Management LP | | 143,800 | $111.11M | HOLD |
| 9 |  State Street State Street Global Advisors | | 4,664,478 | $3.60B | HOLD |
| 10 |  | | 8,947,735 | $6.91B | HOLD |
| 11 |  Goldman Sachs Goldman Sachs Asset Management | | 1,300,558 | $1.00B | HOLD |
| 12 |  | | 55,353 | $42.77M | HOLD |
| 13 |  Jim Simons (Estate) Renaissance Technologies LLC | | 66,802 | $51.61M | HOLD |
| 14 |  Ray Dalio Bridgewater Associates LP | | 22,724 | $17.56M | HOLD |
| 15 |  Fidelity (FMR) Fidelity Management & Research | | 1,518,192 | $1.17B | HOLD |
| 16 |  Ken Griffin Citadel Advisors LLC | | 213,700 | $165.11M | HOLD |
| 17 |  Israel Englander Millennium Management LLC | | 62,730 | $48.47M | HOLD |
| 18 |  David E. Shaw D.E. Shaw & Co LP | | 22,730 | $17.56M | HOLD |
| 19 |  Mario Gabelli GAMCO Investors Inc | | 639 | $493,717 | HOLD |
| 20 |  Dmitry Balyasny Balyasny Asset Management LP | | 1,700 | $1.31M | HOLD |
| 21 |  Ken Fisher Fisher Asset Management LLC | | 5,059 | $3.91M | HOLD |
| 22 |  Paul Tudor Jones Tudor Investment Corp | | 700 | $540,848 | HOLD |
REGN