| 1 |  Joseph Edelman Perceptive Advisors LLC | | 315,541 | $51.70M | HOLD |
| 2 |  Louis Bacon Moore Capital Management LP | | 150,000 | $24.58M | HOLD |
| 3 |  Ron Baron Baron Capital Group Inc | | 544,779 | $89.27M | HOLD |
| 4 |  Steve Cohen Point72 Asset Management LP | | 1,006,310 | $164.89M | HOLD |
| 5 |  T. Rowe Price T. Rowe Price Associates Inc | | 4,599,061 | $753.60M | HOLD |
| 6 |  Israel Englander Millennium Management LLC | | 650,546 | $106.60M | HOLD |
| 7 |  Ken Griffin Citadel Advisors LLC | | 1,394,252 | $228.46M | HOLD |
| 8 |  Joel Greenblatt Gotham Asset Management LLC | | 50,531 | $8.28M | HOLD |
| 9 |  Dmitry Balyasny Balyasny Asset Management LP | | 115,053 | $18.85M | HOLD |
| 10 |  | | 2,867,846 | $469.93M | HOLD |
| 11 |  | | 6,619,271 | $1.08B | HOLD |
| 12 |  Vanguard Vanguard Group Inc | | 4,993,945 | $818.31M | HOLD |
| 13 |  State Street State Street Global Advisors | | 1,719,093 | $281.69M | HOLD |
| 14 |  Norges Bank Norges Bank Investment Management | | 462,094 | $75.72M | HOLD |
| 15 |  Goldman Sachs Goldman Sachs Asset Management LP | | 295,271 | $48.38M | HOLD |
| 16 |  Ray Dalio Bridgewater Associates LP | | 7,874 | $1.29M | HOLD |
| 17 |  JPMorgan Chase JPMorgan Chase & Co | | 248,937 | $40.79M | HOLD |
| 18 |  David E. Shaw D.E. Shaw & Co LP | | 26,300 | $4.31M | HOLD |
| 19 |  Two Sigma Two Sigma Investments LP | | 8,400 | $1.38M | HOLD |
| 20 |  Cliff Asness AQR Capital Management LLC | | 8,648 | $1.42M | HOLD |
| 21 |  Paul Tudor Jones Tudor Investment Corp | | 1,300 | $213,018 | HOLD |
RGEN