| 1 |  Marc Andreessen AH Capital Management LLC | | 921,099 | $89.58M | HOLD |
| 2 |  Julian Baker Baker Brothers Advisors LP | | 9,555,357 | $929.26M | HOLD |
| 3 |  Stanley Druckenmiller Duquesne Family Office LLC | | 315,860 | $30.72M | HOLD |
| 4 |  Joseph Edelman Perceptive Advisors LLC | | 258,600 | $25.15M | HOLD |
| 5 |  Two Sigma Two Sigma Investments LP | | 1,558,807 | $151.59M | HOLD |
| 6 |  Louis Bacon Moore Capital Management LP | | 55,600 | $5.41M | HOLD |
| 7 |  David E. Shaw D.E. Shaw & Co LP | | 1,022,298 | $99.42M | HOLD |
| 8 |  Fidelity (FMR) Fidelity Management & Research | | 8,464,314 | $823.15M | HOLD |
| 9 |  Joel Greenblatt Gotham Asset Management LLC | | 125,901 | $12.24M | HOLD |
| 10 |  T. Rowe Price T. Rowe Price Associates | | 3,232,213 | $314.33M | HOLD |
| 11 |  Goldman Sachs Goldman Sachs Asset Management | | 2,185,500 | $212.54M | HOLD |
| 12 |  | | 11,212,706 | $1.09B | HOLD |
| 13 |  Paul Tudor Jones Tudor Investment Corp | | 87,852 | $8.54M | HOLD |
| 14 |  Israel Englander Millennium Management LLC | | 377,332 | $36.70M | HOLD |
| 15 |  State Street State Street Global Advisors | | 4,402,662 | $428.16M | HOLD |
| 16 |  Ken Fisher Fisher Asset Management LLC | | 215,947 | $21.00M | HOLD |
| 17 |  Dmitry Balyasny Balyasny Asset Management LP | | 50,000 | $4.86M | HOLD |
| 18 |  Ken Griffin Citadel Advisors LLC | | 400,053 | $38.91M | HOLD |
| 19 |  Cliff Asness AQR Capital Management LLC | | 116,787 | $11.36M | HOLD |
| 20 |  JPMorgan Chase JPMorgan Asset Management | | 301,393 | $27.94M | HOLD |
| 21 |  Jim Simons (Estate) Renaissance Technologies LLC | | 6,200 | $602,950 | HOLD |
| 22 |  Ron Baron Baron Capital Group Inc | | 2,500 | $243,125 | HOLD |
| 23 |  Steve Cohen Point72 Asset Management LP | | 2,600 | $252,850 | HOLD |
RVMD