| 1 |  Joseph Edelman Perceptive Advisors LLC | | 2,546,391 | $272.57M | HOLD |
| 2 |  Julian Baker Baker Brothers Advisors LP | | 5,604,483 | $599.90M | HOLD |
| 3 |  Jim Simons (Estate) Renaissance Technologies LLC | | 341,193 | $36.52M | HOLD |
| 4 |  Steve Cohen Point72 Asset Management LP | | 429,420 | $45.97M | HOLD |
| 5 |  Goldman Sachs Goldman Sachs Asset Management LP | | 1,830,866 | $195.98M | HOLD |
| 6 |  T. Rowe Price T. Rowe Price Associates Inc | | 1,560,847 | $167.07M | HOLD |
| 7 |  | | 6,297,334 | $674.07M | HOLD |
| 8 |  Dmitry Balyasny Balyasny Asset Management LP | | 72,282 | $7.74M | HOLD |
| 9 |  Vanguard Vanguard Group Inc | | 6,210,916 | $664.82M | HOLD |
| 10 |  JPMorgan Chase JPMorgan Chase & Co | | 1,423,989 | $152.42M | HOLD |
| 11 |  | | 1,706,317 | $182.64M | HOLD |
| 12 |  Israel Englander Millennium Management LLC | | 186,709 | $19.99M | HOLD |
| 13 |  State Street State Street Global Advisors | | 2,198,615 | $235.34M | HOLD |
| 14 |  Cliff Asness AQR Capital Management LLC | | 70,046 | $7.50M | HOLD |
| 15 |  Ken Griffin Citadel Advisors LLC | | 153,322 | $16.41M | HOLD |
| 16 |  David E. Shaw D.E. Shaw & Co LP | | 31,356 | $3.36M | HOLD |
| 17 |  Joel Greenblatt Gotham Asset Management LLC | | 4,851 | $519,251 | HOLD |
| 18 |  Norges Bank Norges Bank Investment Management | | 66,213 | $7.09M | HOLD |
RYTM