| 1 |  Joseph Edelman Perceptive Advisors LLC | | 2,373,795 | $206.45M | HOLD |
| 2 |  Julian Baker Baker Brothers Advisors LP | | 5,604,483 | $487.42M | HOLD |
| 3 |  Steve Cohen Point72 Asset Management LP | | 846,801 | $73.65M | HOLD |
| 4 |  Jim Simons (Estate) Renaissance Technologies LLC | | 258,011 | $22.44M | HOLD |
| 5 |  Ken Griffin Citadel Advisors LLC | | 1,418,619 | $123.38M | HOLD |
| 6 |  Goldman Sachs Goldman Sachs Asset Management | | 1,965,432 | $170.93M | HOLD |
| 7 |  Israel Englander Millennium Management LLC | | 451,825 | $39.30M | HOLD |
| 8 |  T. Rowe Price T. Rowe Price Associates | | 1,654,876 | $143.93M | HOLD |
| 9 |  | | 6,237,151 | $542.45M | HOLD |
| 10 |  Fidelity (FMR) Fidelity Management & Research | | 1,689,671 | $146.95M | HOLD |
| 11 |  JPMorgan Chase JPMorgan Asset Management | | 1,553,644 | $120.02M | HOLD |
| 12 |  State Street State Street Global Advisors | | 2,271,851 | $197.58M | HOLD |
| 13 |  Dmitry Balyasny Balyasny Asset Management LP | | 52,967 | $4.61M | HOLD |
| 14 |  Paul Tudor Jones Tudor Investment Corp | | 19,646 | $1.71M | HOLD |
| 15 |  Cliff Asness AQR Capital Management LLC | | 59,279 | $5.16M | HOLD |
| 16 |  David E. Shaw D.E. Shaw & Co LP | | 32,652 | $2.84M | HOLD |
| 17 |  Joel Greenblatt Gotham Asset Management LLC | | 4,848 | $421,631 | HOLD |
| 18 |  Two Sigma Two Sigma Investments LP | | 4,300 | $373,971 | HOLD |
RYTM